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In order to determine -E, adrenocorticotropic hormone ACTH, cortisol C. An improvement in FEV1and dyspnea score at the end of Acu-TENS treatment was associated with a concurrent increase in β-endorphin level in patients with COPD. Twelve non-specifically trained volunteers (aged 26.5 years, SD 3.6) performed exhausting incremental graded exercise (ST) and 1-min anaerobic cycle ergometer exercise (AnT) at 2-h intervals for the purpose of investigating -endorphin (-E) behaviour dependent on exercise intensity and anaerobic metabolism.Furthermore, the percentage reduction in RR correlated with the increase in β-endorphin (R = -0.477, P =.033). The postintervention increase in β-endorphin was significantly higher in the acu-TENS than the placebo group (18.3%) (P =.027). 1 It binds to rat and mouse brain membrane preparations (IC 50 s 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM. The decrease in RR and DVAS was also more in the acu-TENS group by 14.2% (P <.0001) and 20.7% (P =.006), respectively. Endorphin (1-27) is an endogenous peptide that binds to -, -, and -opioid receptors (K i s 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors).
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Our findings showed that the increase in FEV1was 24.2% greater in the acu-TENS group than the placebo group (P FEV1, forced vital capacity (FVC), dyspnea visual analogue score (DVAS), respiratory rate (RR), and blood β-endorphin levels were measured before and after therapeutic intervention.Participants were randomly assigned to receive either acu-TENS or placebo-TENS on Dingchuan (EX-B1) for 45 minutes.
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In addition, -endorphin also exerts a direct. Official Title: Beta-Endorphin as a Mediator of Cancer Therapy-Induced Fatigue. Also the -endorphin-induced enhancement of the natural killer cell activity may suppress the B cell function. Forty-four subjects diagnosed with COPD Intervention Based in our finding in mice, the investigators expect -endorphin levels.